Botanical name : Tabernaemontana divaricata (Linn.) R.Br. ex Roem & Schultes
Family : Apocynaceae
Nandeevriksha, Khsirika, Ksheeri, Vishnupriya
Rasa : Katu, Tikta
Guna : Lakhu
Virya : Seeta
Vipaka : Katu
PLANT NAME IN DIFFERENT LANGUAGES
English : East Indian rosebay
Hindi : Tagar ,Chameli, Chandini
Malayalam : Nandyarvattam, Nandyarvartham
Distribution – Throughout India, cultivated as garden plant.
An evergreen, much branched shrub grows up to 2.5 meters in height. Leaves simple, opposite, elliptic-lanceolate, covered with cuticle; flowers white fragrant, in axillary or terminal cymes; fruits follicles, ribbed and curved, orange or bright red colored; seeds dull brown, enclosed in the pulpy aril. Reproduction usually by vegetative manner.
Plant pacifies vitiated vata, pitta, diseases of the eye, headache, skin diseases, bleeding disorder, itching, and arthritis.
Useful part : Root, Flowers, Latex.
RESEARCH : Pharmacological properties exhibited by latex of plants are due to various biologically active compounds including several proteolytic enzymes. Present study evaluates hemostatic potential of Tabernaemontana divaricata and Artocarpus altilis from Apocynaceae and Moraceae families respectively. The latex of these plants were initially subjected to dialysis and crude extracts were estimated for proteolytic activity using casein as the substrate. Mean caseinolytic activity for 100 µg of latex protein was found to be 56.16 ± 0.57 and 45 ± 0.3 U/h for T. divaricata and A. altilis respectively. Caseinolytic activity by both the plant extracts was higher than standard proteases, papain and trypsin. However the difference was significant (p < 0.05) with papain alone. Crude enzymes (CE) from both plants exhibited coagulant activity on human platelet poor plasma by recalcification time. A significant reduction in clotting time was exhibited by T. divaricata compared to A. altilis (p < 0.05). These results were further substantiated with fibrinogen agarose plate assay. Crude enzyme of both plants also hydrolyzed blood clot. Mean % of thrombolysis by T. divaricata was 80.75 ± 1.2 and that of A. altilis was 70.24 ± 1.52. Inhibition studies confirmed cysteine protease nature of CE. Comparative analysis revealed T. divaricata to be the best among the two for its hemostatic potential. This study scientifically validates the use of latex from these plants in the management of fresh cuts or wounds