Name: JYOTISHMATI ( ज्योतिष्मती )

Botanical name : Celastrus paniculatus Willd.
Family : Celastraceae
Jyotishmati, Tejovati, Bahuphala, Peetataila
Rasa    : Katu, Tikta
Guna   : Snigdha, Sara, Teekshna
Virya   : Ushna
Vipaka : Katu
Prabhava : Medhya
English     : Black oil tree, Climbing staff plant
Hindi        : Malkangani, Malkunki
Malayalam    : Cherupunna, Kiliteenipanji, Valuzhavam
Distribution – Throughout India growing wild in dry deciduous forests.
A large climbing shrub with woody stem and elongate brances. Leaves simple, alternate, ovate – obovate, crenulate, coriaceous, flowers greenish white, in terminal panicles. Fruits capsules yellow colored, become bright red when ripe, contain 4 brown seeds.
Plant pacifies vitiated vata, kapha, mental retardation, skin diseases, itching, hemiplegia, arthritis, asthma, insomnia, amnesia, urinary retention and nephritis. Seeds widely used in intellect promoting ayurvedic combinations.
Useful part : Root, Leaves, Seeds
Research : The effect of Celastrus paniculatus Willd. (Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). The aqueous seed extract was administered orally in two different doses to rats (350 and 1050 mg/kg) and to mice (500 and 1500 mg/kg). The results were compared to piracetam (100 mg/kg, p.o.) used as a standard drug. Chemical hypoxia was induced by subcutaneous administration of sodium nitrite (35 mg/kg), immediately after acquisition training. In elevated plus maze and sodium nitrite-induced amnesia model, Celastrus paniculatus extract has showed statistically significant improvement in memory process when compared to control. The estimation of acetylcholinesterase enzyme in rat brain supports the plus maze and passive avoidance test by reducing acetylcholinesterase activity which helps in memory performance. The study reveals that the aqueous extract of Celastrus paniculatus seed has dose-dependent cholinergic activity, thereby improving memory performance. The mechanism by which Celastrus paniculatus enhances cognition may be due to increased acetylcholine level in rat brain.
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